Oligofructose-enriched inulin improves some inflammatory markers and metabolic endotoxemia in women with type 2 diabetes mellitus
Nutrition. 2014 Apr;30(4):418-23.
Dehghan P, Pourghassem Gargari B, Asghari Jafar-abadi M.
Anti-inflammatory therapeutic approaches are considered for the management of type2diabetes and for the prevention of its complications. There is limited evidence regarding the effects of prebiotics on inflammation, especially in patients with type2diabetes. This trial aims to examine the effects of oligofructose-enrichedinulin on glycemic status, inflammation markers, and metabolicendotoxemia in female patients.
Over a period of 8 wk, 52 women with body mass indices of >25 kg/m(2) but 35 kg/m(2) with type2diabetes were randomly assigned to either an intervention group, in which participants were given oligofructose-enrichedinulin (n = 27, consuming 10 g/d of oligofructose-enrichedinulin), or to a control group, in which participants were given maltodextrin (n = 25, consuming 10 g/d of maltodextrin). Fasting plasma glucose, glycosylated hemoglobin, high-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor-α, interferon-γ, interleukin-10, and plasma lipopolysaccharide were measured before and after the intervention. Data were analyzed with the use of SPSS software version 13. Paired and unpaired Student t tests and analysis of covariance were used to compare quantitative variables.
Oligofructose-enrichedinulin caused a significant decrease in the levels of fasting plasma glucose (19.2 mg/dL; 9.50%), glycosylated hemoglobin (1.0%; 8.40%), interleukin-6 (1.3 pg/mL; 8.15%), tumor necrosis factor-α (3.0 pg/mL; 19.80%) and plasma lipopolysaccharide (6.0 EU/mL; 21.95%) as compared with maltodextrin (P 0.05). Decreases in levels of interferon-γ (0.3 pg/mL; 16.50%) and high-sensitivity C-reactive protein (3.9 ng/mL; 31.70%) and an increase in the level of interleukin-10 (0.4 pg/mL, 11.50%) were not significant in the oligofructose-enrichedinulin group as compared with the maltodextrin group.
In women with type2diabetes and suboptimal daily dietary fiber intake, oligofructose-enrichedinulin may help to modulate some inflammatorymarkers.